Dodonaea viscosa Jacq. Induces cytotoxicity, antiproliferative activity, and cell death in colorectal cancer cells via regulation of caspase 3 and p53

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dc.contributor.authorPeña Rojas, Gilmar
dc.contributor.authorAndía Ayme, Vidalina
dc.date.accessioned2025-03-08T02:07:30Z
dc.date.available2025-03-08T02:07:30Z
dc.date.issued2023
dc.description.abstractColorectal cancer (CRC) is the third most common cancer diagnosed worldwide and is the second leading cause of cancer-related death due to an insuf?ciency prognosis and is generally diagnosed in the last step of development. The Peruvian ?ora has a wide variety of medicinal plants with therapeutic potential in several diseases. Dodonaea viscosa Jacq. is a plant used to treat in?ammatoryprocessaswellas gastrointestinal diseases. The aim of this study was to examine the cytotoxic, antiproliferative, and cell death-inducing effects of D. viscosa on colorectal cancer cells (SW480 and SW620). The hydroethanolic extract was obtained by maceration at 70% ethanol, the phytochemical constituents were identi?ed by LC-ESI-MS.D. viscosa revealed 57 compounds some of them are: isorhamnetin, kaempferol, quercetin, methyl dodovisate B, hardwickiic acid, viscosol, and dodonic acid. Regarding the antitumoral activity, D. viscosa induced cytotoxic and antiproliferative activity in both SW480 and SW620 cancer cells, accompanied with, important changes in mitochondrial membrane potential, formation of the Sub G0/G1 population and increasing levels of apoptotic biomarkers (caspase 3 and the tumor suppressor protein p53) in the metastatic derivative cell line (SW620), suggesting an intrinsic apoptotic process after the treatment with the hydroethanolic extract of D. viscosa.es_PE
dc.description.uriArtículo Científicoes_PE
dc.formatapplication/pdf
dc.identifier.otherArtículo Científico 6_Peñ
dc.identifier.urihttps://repositorio.unsch.edu.pe/handle/20.500.14612/7544
dc.language.isoenes_PE
dc.publisherUniversidad Nacional de San Cristóbal de Huamangaes_PE
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceUniversidad Nacional de San Cristóbal de Huamangaes_PE
dc.sourceRepositorio Institucional - UNSCHes_PE
dc.subjectDodonaea viscosaes_PE
dc.subjectMedicinal plantes_PE
dc.subjectColorectal canceres_PE
dc.subjectPhytochemical screeninges_PE
dc.subjectCell deathes_PE
dc.titleDodonaea viscosa Jacq. Induces cytotoxicity, antiproliferative activity, and cell death in colorectal cancer cells via regulation of caspase 3 and p53es_PE
dc.typeinfo:eu-repo/semantics/articleen_US
renati.advisor.orcidhttps://orcid.org/0000-0002-1888-4989
renati.advisor.orcidhttps://orcid.org/0000-0002-7951-3241
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