In silico evaluation of Dodonic Acid from Dodonaea viscosa Jacq on target Proteins from Staphylococcus aureus

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dc.contributor.authorAndía Ayme, Vidalina
dc.contributor.authorPeña Rojas, Gilmar
dc.date.accessioned2025-03-08T02:07:27Z
dc.date.available2025-03-08T02:07:27Z
dc.date.issued2022
dc.description.abstractDodonaea viscosa Jacq is known as “chamana” in the popular flora of Peru. the traditional medicine uses its leaves as ingredient in fermented beverages from Zea mays and also in external uses for antiinflammatory diseases. The aim was to study the role of dodonic acid against several protein targets of S. aureus. this study was focused on to analyse the role of dodonic acid against S. aureus target proteins such as on sortase-A, DNA gyrase, dihydrofolate reductase (DhFR), clumping factor, dehydrosqualene synthase, and undecaprenyl di-phosphate synthase as a promising candidate molecule. the docking analysis of dodonic acid showed the best docking score energy on S. aureus undecaprenyl diphosphate synthase with -11.2 kcal/mol and demonstrated to be a very stable molecule at physiological conditions during the molecular dynamic for 50 ns. As conclusion, the extract demonstrated to be active against S. aureus and dodonic acid might be a promising molecule acting on the S. aureus undecaprenyl diphosphate synthase.es_PE
dc.description.uriArtículo Científicoes_PE
dc.formatapplication/pdf
dc.identifier.otherArtículo Científico 1_And
dc.identifier.urihttps://repositorio.unsch.edu.pe/handle/20.500.14612/7537
dc.language.isoenes_PE
dc.publisherUniversidad Nacional de San Cristóbal de Huamangaes_PE
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceUniversidad Nacional de San Cristóbal de Huamangaes_PE
dc.sourceRepositorio Institucional - UNSCHes_PE
dc.subjectDodoviscines_PE
dc.subjectAntibacteriales_PE
dc.subjectDocking Analysises_PE
dc.subjectMolecular Dynamices_PE
dc.subjectMedicinal Plantses_PE
dc.subjectIn-silicoes_PE
dc.titleIn silico evaluation of Dodonic Acid from Dodonaea viscosa Jacq on target Proteins from Staphylococcus aureuses_PE
dc.typeinfo:eu-repo/semantics/articleen_US
renati.advisor.orcidhttps://orcid.org/0000-0002-7951-3241
renati.advisor.orcidhttps://orcid.org/0000-0002-1888-4989
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